##  [Regulatory Roundup - June 03, 2024](/index%2Ephp/regulatory-roundup/week-of-june-03-2024) 

[Back to Regulatory Roundup Archive](/regulatory-roundup)



## Top Industry News

- [EU Scientific Committee Assesses Safety of Titanium Dioxide in Oral Cosmetic Products](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fhealth.ec.europa.eu%2Fpublications%2Fscientific-advice-titanium-dioxide-tio2-casec-numbers-13463-67-7236-675-5-1317-70-0215-280-1-1317-80_en&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089306578%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=npRycRN8067vw9uY5xhf%2BLF50KeL1Wn1kcVQERmU2AA%3D&reserved=0)
- [FDA Draft Guidance on Platform Technology Designation Program for Drug Development](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fda.gov%2Fmedia%2F178938%2Fdownload&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089320780%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=3lYG5xjWwOJp61OSLq%2BJ52LynVZ0bKyXyGDpsCXmtIw%3D&reserved=0)
- [ANVISA Approves New Regulation For Registration Of Biosimilar Medicines](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.gov.br%2Fanvisa%2Fpt-br%2Fassuntos%2Fnoticias-anvisa%2F2024%2Fanvisa-aprova-novo-regulamento-para-registro-de-medicamentos-biossimilares&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089325054%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=JjGa6GlUgV5hHu8BcllWwwLYWtb7hxx98YWHwVNBVNg%3D&reserved=0)
- [CFIA Launches Consultation on Safe Food for Canadians Act to Enhance Food Safety and Market Access](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Finspection.canada.ca%2Fen%2Fabout-cfia%2Ftransparency%2Fconsultations-and-engagement%2Flegislative-review&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089329210%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=NFRHvSVsg48IC7zfBHTXIFXhYaogF8Bp0zsNYba2QdA%3D&reserved=0)
- [FSA Publishes New Consumer Guidance on Ultra-Processed Foods and Healthy Eating](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.food.gov.uk%2Fnews-alerts%2Fnews%2Fpublication-of-consumer-information-on-ultra-processed-food&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089333622%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=BAY6TI6OQIwNJkXDyxlZVT7R4YpMgO1d1XR9MfRh%2FXE%3D&reserved=0)
- [EU Council Adopts Amendments Delaying IVDR Deadlines](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.consilium.europa.eu%2Fen%2Fpress%2Fpress-releases%2F2024%2F05%2F30%2Fmedical-devices-council-adopts-new-measures-to-help-prevent-shortages%2F&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089337645%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=p4IIniVohPwdI6BL91R%2FcmE3p3y%2FY8JxPuYolAhrP84%3D&reserved=0)
- [FDA Enhances Searchable Tobacco Products Database with Improved Search and Mobile Accessibility](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Ffda-roundup-may-24-2024&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089341705%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=rfuYcKqlLzXA%2F8gUlxXvyh7YUxEJz5rTxLFlY0%2BbxTc%3D&reserved=0)
- [Swissmedic - Adaptation of the Guideline Changes and Authorisation Extensions Human Medicinal Products(HAM)](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.swissmedic.ch%2Fswissmedic%2Fde%2Fhome%2Fhumanarzneimittel%2Fauthorisations%2Finformationen%2Fanpassung-wl-ae-zlerweiterung-ham.html&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089345733%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=PUDDKsYWtmjeoWfTEdRtFgVNVgWYWY%2BzkE74fStUwkk%3D&reserved=0)
- [FDA Declares Tara Flour Unsafe for Human Consumption, Cites Lack of GRAS Status](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.fda.gov%2Fnews-events%2Fpress-announcements%2Ffda-roundup-may-17-2024&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089349789%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=4HsZFnp5OJbd10bpqTdNS%2BAA6BIBv4lcNrpadjq2r8w%3D&reserved=0)
- [Chile ISP Implements New Regulatory Guidance for Conducting Clinical Studies](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.ispch.cl%2Fnoticia%2Fisp-implementa-nueva-guia-normativa-para-la-realizacion-de-estudios-clinicos%2F&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089354177%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=Qm5Bb2byRDsRwS6YVJv4tKODqzz0h9pwd2NpwYgdepw%3D&reserved=0)
- [ANVISA has Incorporated Mercosur/GMC/RES. No. 48/2023 into its National Legislation via RDC No. 854/2024, Updating Sanitary Requirements for Food Contact Metals and Alloys, Effective October 29, 2024](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fantigo.anvisa.gov.br%2Flegislacao%23%2Fvisualizar%2F518462&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089358299%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=QI8Dm27zUM5Zf%2FUZDQoZ4Y4YrGFw9s%2FOFPQIVvSZ1cQ%3D&reserved=0)
- [US EPA \| Comprehensive Guide to Chemical Reporting Requirements: Consolidated List of Lists (EPCRA, CERCLA, and CAA)](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.epa.gov%2Fsystem%2Ffiles%2Fdocuments%2F2024-05%2Fepcra-cercla-caa-112r-consolidated-list-of-lists-updated-may-2024_0.pdf&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089362330%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=wPdPKjryessf5W57Eo2CAK6Q53zBMgdt%2FbMpthA9jWM%3D&reserved=0)
- [MDA - Latest Policy Updates & Medical Device Industry Dialogue](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fportal.mda.gov.my%2Findex.php%2Fannouncement%2F1407-latest-policy-updates-medical-device-industry-dialogue&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089366358%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=txPEUlqQn32wWnC0unzeeKAAp5wEqXyVKXtNGy4mT8w%3D&reserved=0)
- [ANVISA Approves National Prescription Control System](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.gov.br%2Fanvisa%2Fpt-br%2Fassuntos%2Fnoticias-anvisa%2F2024%2Fanvisa-aprova-sistema-nacional-de-controle-de-receituario-sncr&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089370695%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=D1sfKW9fxVf52PJlFRWTU9A3wYr3LzFSNGpouq3Zvck%3D&reserved=0)
- [NPRA - Revision of Timelines For Variation Applications Of Registered Products \[pharmaceutical products & natural and health supplement products (TMHS)\] and a pilot study](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fnpra.gov.my%2Findex.php%2Fen%2Fcomponent%2Fcontent%2Farticle%2F453-english%2Fannouncement-main%2Fannouncement-2024%2F1527611-revision-of-timelines-for-variation-applications-of-registered-products-pharmaceutical-products-natural-and-health-supplement-products-tmhs-and-a-pilot-study-2.html%3FItemid%3D1391&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089374778%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=wqNQNt5qenutE1BpfhzTVvM%2BZ9aSQpathRSGbnOYx%2Bs%3D&reserved=0)
- [SFDA’s Guidance on the Equivalence of Topical Products](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.sfda.gov.sa%2Fsites%2Fdefault%2Ffiles%2F2024-06%2FEquivalanceTopicalProducts.pdf&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089379062%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=mAgEnRWyR5CL1jW525gVaDUIvev03Ibe6f2DvZYb3Wg%3D&reserved=0)
- [ANVISA Authorizes Donation Of Medicines To Health Departments in Rio Grande do Sul](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.gov.br%2Fanvisa%2Fpt-br%2Fassuntos%2Fnoticias-anvisa%2F2024%2Fanvisa-autoriza-doacao-de-medicamentos-para-secretarias-de-saude-do-rio-grande-do-sul&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089383122%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=lyRKqCGYAu4PoEsrQZF2TzbGqkC51LNVNUSPowYKdJ4%3D&reserved=0)

## Mergers & Acquisitions

- [Fusion Pharmaceuticals Shareholders Approve Acquisition by AstraZeneca](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fir.fusionpharma.com%2F2024-05-29-Fusion-Pharmaceuticals-Shareholders-Approve-Acquisition-by-AstraZeneca&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089387259%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=AMPh1ZNl%2B7Y5LPhKiee4K3NYRCampuFbdeawjgRqH%2Fc%3D&reserved=0)
- [Sanofi Completes Acquisition of Inhibrx, Inc](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biospace.com%2Farticle%2Freleases%2Fpress-release-sanofi-completes-acquisition-of-inhibrx-inc-%2F%3Fs%3D79&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089391352%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=hEC8g1GjCQO%2FAd5XFOI%2B1hkVb5DnCaVqIJbCY6dr9TM%3D&reserved=0)
- [Incyte Completes Acquisition Of Escient Pharmaceuticals](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Finvestor.incyte.com%2Fnews-releases%2Fnews-release-details%2Fincyte-completes-acquisition-escient-pharmaceuticals&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089395483%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=Zk7CdGZ3%2B%2FVIdzJArEchV%2F7JUC7zA0eO67mXU7%2Fby7I%3D&reserved=0)
- [Atrion Corporation Enters Into Merger Agreement with Nordson Corporation](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fatrion.irpass.com%2Fprofiles%2Finvestor%2FNewsPrint.asp%3Fv%3D6%26b%3D611%26ID%3D134671%26m%3Drl%26g%3D328&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089399629%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=eyzmRlY6X5Wyppv3yWh%2FGwag1e7VuPmk8wCYvEsFkE0%3D&reserved=0)



## Upcoming Events

- [BIO Asia - Taiwan 2024](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fbioasiataiwan.com%2Fen%2Fabout%2Fdetail%2F1&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089416120%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=5yhf%2BJlJ5%2B%2BjSb%2F9vXlV7VgXAyffsZQEfceNAbwZm0I%3D&reserved=0)
- [International Medical Device Exhibition & Conference (IMDEC 2024)](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fimdecmy24.mda.gov.my%2F&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089420171%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=9gdNRlaxhcfK7Woa38%2FWBOwudiKM16wZSg3plfb2rg8%3D&reserved=0)

## Blog Posts

- [Synopsis of FDA's New Clinical Trial Innovation Center (C3TI)](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.freyrsolutions.com%2Fblog%2Fsynopsis-of-fdas-new-clinical-trial-innovation-center-c3ti&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089424129%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=M0xcqd4ZpwTmTV%2FZO1xy73N%2BRJn8lMIGppWGjEMe%2F6U%3D&reserved=0)
- [Strategic Regulatory Planning- The New Regulatory Way](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.freyrsolutions.com%2Fblog%2Fstrategic-regulatory-planning-the-new-regulatory-way&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089428146%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=YmX1BlTxQ4%2FDHvEfFMUAQY%2FIC8OA312jVZM9i0M%2BPcM%3D&reserved=0)
- [Key Updates: Korea's Adoption of MDSAP](https://apc01.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.freyrsolutions.com%2Fblog%2Fkey-updates-koreas-adoption-of-mdsap&data=05%7C02%7Cdinesh.m%40FreyrSolutions.com%7Cbcc25cffe9ec496e89f008dc83c7f78a%7Ce1dffae5ca2f4d3fba9531318bc48aae%7C0%7C0%7C638530142089432191%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C0%7C%7C%7C&sdata=PrZAjJ124iRKuSis3l7BeWpemejPGAu9L%2Fx8bi8lfxM%3D&reserved=0)