,The Cosmetic Ingredient Review (CIR) Expert Panel prepared a draft safety assessment and evaluated three phosphine-derived cosmetic ingredients: Bis-Trimethylbenzoyl Phenylphosphine Oxide, Ethyl Trimethylbenzoyl Phenylphosphinate, and Trimethylbenzoyl Diphenylphosphine Oxide. It is a Draft Tentative Report released on 17 February 2026 for panel review ahead of the March 2026 meeting. The assessment outlines the review process, including the 60-day public comment period, historical report progress, and changes made since previous drafts. Due to structural similarities, the panel added two ingredients in 2025 for evaluation. The report provides background on industry use concentrations and identifies data gaps, such as insufficient dermal irritation, sensitization, and ocular data. It includes toxicological profiles, exposure data, and an analysis of how widespread these ingredients are in cosmetic products like nail polish, enamel, and hair preparations. A key focus is calculating the Margin of Exposure (MOE), considering updated use data and reviewing previous safety conclusions. The report mentions EU classifications — for example, Trimethylbenzoyl Diphenylphosphine Oxide is noted as potentially toxic for reproduction under EU regulations — and summarized the decision pathway toward tentative conclusions.
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