The Cosmetic Ingredient Review (CIR) Expert Panel conducted a comprehensive safety evaluation, analyzing all available toxicological data, including published studies and industry submissions. The review focused on seven specific dimer dilinoleate variants, assessing their potential for skin irritation, sensitization, and systemic toxicity. Dimer dilinoleates are a class of ester compounds derived from dilinoleic acid, commonly used in cosmetic formulations. These ingredients function primarily as skin and hair conditioning agents and viscosity enhancers, improving product texture, spreadability, and overall sensory experience. Their chemical structure is created by reacting dilinoleic acid—a dimer of linoleic acid—with various alcohols, resulting in subtle variations that tailor their performance in different cosmetic applications. In conclusion, dimer dilinoleates are considered safe for their intended cosmetic uses, offering functional benefits while maintaining a favorable safety profile, making them reliable ingredients in modern skincare and haircare products.