,On October 25, 2025, the Government of Canada published an updated notice of intent in the Canada Gazette, Part I to amend the Domestic Substances List (DSL) and apply Significant New Activity (SNAc) provisions under the Canadian Environmental Protection Act, 1999 (CEPA) to Diisodecyl adipate (DIDA; CAS RN 27178-16-1). This follows the final screening assessment under the Chemicals Management Plan (CMP), which concluded that DIDA does not meet the criteria of section 64 of CEPA, meaning it is not harmful at current exposure levels. However, potential developmental toxicity identified as an effect of concern prompted the application of SNAc provisions to manage possible future risks if exposure increases. Earlier consultations in 2019 informed adjustments to the scope of SNAc requirements. Another related substance, nonanedioic acid, bis(2-ethylhexyl) ester (CAS RN 103-24-2), was deemed of low concern through a separate risk assessment approach.
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