,"The U.S. Environmental Protection Agency (EPA) has issued a final rule establishing a pesticide tolerance for residues of fluopyram (CASRN 658066-35-4) in or on mango at 1.0 parts per million (ppm). The rule, published in the Federal Register Vol. 90, No. 220 on November 18, 2025, amends 40 CFR §180.661 to include mango in the list of commodities permitted to contain fluopyram residues.
The tolerance was requested by the U.S. Department of Agriculture – Foreign Agricultural Service (USDA-FAS) under a pesticide petition (PP 3E9060) filed with EPA. EPA evaluated the petition under FFDCA section 408, determining that the tolerance level is “safe” and poses “a reasonable certainty of no harm” to the general population, including infants and children.
EPA’s assessment relied on previously published toxicological and risk evaluations and found no carcinogenic risk associated with fluopyram. Acute and chronic dietary risk estimates remain unchanged from earlier assessments. The agency also harmonized its action with international standards—the Codex Alimentarius already sets an MRL of 1 ppm for fluopyram in mangoes, identical to the newly established U.S. tolerance.
The final rule becomes effective November 18, 2025. Parties wishing to file objections or request hearings must do so by January 20, 2026, following procedures in 40 CFR part 178 and referencing docket ID EPA-HQ-OPP-2024-0176.
EPA noted that the rule is exempt from review under Executive Order 12866, and does not trigger requirements under other regulatory statutes such as the Paperwork Reduction Act, Regulatory Flexibility Act, or Unfunded Mandates Reform Act. The rule is also not considered a “major rule” under the Congressional Review Act.
The amendment was signed on November 3, 2025, by Charles Smith, Director of EPA’s Registration Division."