,"On 24 September 2025, ECHA opened a consultation inviting third parties to submit scientifically valid data and studies to avoid unnecessary vertebrate testing under REACH. The deadline for submitting information is 10 November 2025. The proposals cover repeated dose toxicity, developmental toxicity, genetic toxicity in vivo, long-term aquatic toxicity, and bioaccumulation.
The following substances and hazard endpoints are under consultation:
1. 1(4)-butanesultone
- 7.6.2 Genetic toxicity in vivo
2. Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene)
- 7.5.1 Repeated dose toxicity: oral
- 7.8.1 Toxicity to reproduction
- 7.8.2 Developmental toxicity / teratogenicity - species: rabbit
- 7.8.2 Developmental toxicity / teratogenicity – species: rat
3. Distillates (petroleum), full-range straight-run middle
- 6.1.2 Long-term toxicity to fish
- 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Distillates (petroleum), heavy straight-run (EC no. 272-817-2, CAS no. 68915-96-8)
- 7.6.2 Genetic toxicity in vivo||Note: testing proposed with Distillates (petroleum), heavy straight-run (EC no. 272-817-2, CAS no. 68915-96-8)
- 7.6.2 Genetic toxicity in vivo||Note: testing proposed with Distillates (petroleum), straight-run middle (EC no. 265-044-7, CAS no. 64741-44-2)
4. Distillates (petroleum), heavy straight-run
- 6.1.2 Long-term toxicity to fish||Note: testing proposed with Distillates (petroleum), full-range straight-run middle (EC no. 272-341-5, CAS no. 68814-87-9)
- 7.5.1 Repeated dose toxicity: oral
- 7.6.2 Genetic toxicity in vivo
- 7.6.2 Genetic toxicity in vivo||Note: testing proposed with Distillates (petroleum), straight-run middle (EC no. 265-044-7, CAS no. 64741-44-2)
5. Distillates (petroleum), hydrodesulfurized middle
- 6.1.2 Long-term toxicity to fish
6. Distillates (petroleum), hydrotreated middle
- 6.1.2 Long-term toxicity to fish||Note: testing proposed with Distillates (petroleum), hydrodesulfurized middle (EC no. 265-183-3)
7. Distillates (petroleum), straight-run middle
- 6.1.2 Long-term toxicity to fish||Note: testing proposed with Distillates (petroleum), full-range straight-run middle (EC no. 272-341-5, CAS no. 68814-87-9)
- 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Distillates (petroleum), heavy straight-run (EC no. 272-817-2, - CAS no. 68915-96-8)
- 7.6.2 Genetic toxicity in vivo
- 7.6.2 Genetic toxicity in vivo||Note: testing proposed with Distillates (petroleum), heavy straight-run (EC no. 272-817-2, CAS no. 68915-96-8)
8. Dodecene, branched
- 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6)
- 7.8.1 Toxicity to reproduction||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6)
- 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6) – species: rabbit
- 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6) – species: rat
9. Gas oils (petroleum), hydrodesulfurized
- Long-term toxicity to fish||Note: testing proposed with Distillates (petroleum), hydrodesulfurized middle (EC no. 265-183-3)
10. Gas oils (petroleum), straight-run
- 6.1.2 Long-term toxicity to fish || Note: testing proposed with Distillates (petroleum), full-range straight-run middle (EC no. 272-341-5, CAS no. 68814-87-9)
- 7.5.1 Repeated dose toxicity: oral|| Note : testing proposed with Distillates (petroleum), heavy straight-run (EC no. 272-817-2, CAS no. 68915-96-8)
- 7.6.2 Genetic toxicity in vivo || Note: testing proposed with Distillates (petroleum), heavy straight-run (EC no. 272-817-2, CAS no. 68915-96-8)
- 7.6.2 Genetic toxicity in vivo || Note: testing proposed with Distillates (petroleum), straight-run middle (EC no. 265-044-7, CAS no. 64741-44-2)
11. Hydrocarbons, C4, 1,3-butadiene-free, polymd., triisobutylene fraction
- 7.5.1 Repeated dose toxicity: oral||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6)
- 7.8.1 Toxicity to reproduction||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6)
- 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6) – species: rabbit
- 7.8.2 Developmental toxicity / teratogenicity||Note: testing proposed with Butene, homopolymer (products derived from either/or But-1-ene/But-2-ene) (EC no. 500-004-7, CAS no. 9003-29-6) – species: rat
12. Potassium tetrafluoroborate
- Long-term toxicity to fish
Stakeholders are encouraged to provide relevant data by the deadline. All submitted information will support regulatory decisions and help minimise the need for new animal testing."