European Union initiates evidence call for evaluating toluene occupational exposure limits

On 1 April 2026, the European Chemicals Agency (ECHA) launched a call for comments and evidence to support the scientific evaluation of occupational exposure limits (OELs) for toluene. The substance is identified by EC Number 203-625-9 and CAS Number 108-88-3. No dossier submitter is specified, as this initiative is part of a broader evidence-gathering process rather than a harmonised classification proposal. The call, open until 1 July 2026, aims to gather comprehensive scientific information related to workplace exposure, including data on uses, exposure levels, toxicology, epidemiology, health effects, and modes of action. Toluene is currently classified under Annex VI of the CLP Regulation as Reproductive Toxicity Category 2 (Repr. 2), Specific Target Organ Toxicity - Single Exposure Category 3 (STOT SE 3), Specific Target Organ Toxicity - Repeated Exposure Category 2 (STOT RE 2), and Skin Irritation Category 2 (Skin Irrit. 2), indicating risks such as potential harm to the unborn child, drowsiness or dizziness, organ toxicity, and skin irritation.