The European Chemicals Agency (ECHA) maintains a list of Current Candidates for Substitution (CfS) and associated derogation conditions under the Biocidal Products Regulation (BPR). These substances are identified because they meet criteria indicating that they may pose higher concerns for human health or the environment, such as being carcinogenic, mutagenic, reprotoxic (CMR), persistent, bioaccumulative, toxic (PBT), or endocrine disrupting. As a result, they are prioritised for possible substitution with safer alternatives. In parallel, ECHA assesses whether limited derogations (exceptions) can be granted under strict conditions when no suitable alternatives exist and when risks are considered negligible or outweighed by socio-economic benefits. For active substances classified as candidates for substitution, Member States must evaluate alternatives during authorisation procedures and prefer safer chemical or non-chemical options where feasible. Article 5(1) excludes certain hazardous substances unless Article 5(2) derogations apply, such as negligible exposure, essential use, or disproportionate impact. Availability of alternatives is central to decisions. Approved derogations may last up to five years with restricted uses, and Member States may further limit authorisations nationally. ECHA gathers third-party input on alternatives and justification evidence. Current consultation includes alphachloralose (CAS 15879-93-3, EC 240-016-7), a rodenticide (PT 14) for indoor mouse control. The consultation runs from June 15, 2026, to August 13, 2026, with comments submitted online.
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